Topics

Literature reviews

Pharmacokinetics, safety and efficacy

Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge (2023)

2023 Alessandra Di Salvo, Maria Beatrice Conti, Giorgia della Rocca

Pharmacokinetics, safety and efficacy

Pharmacokinetics, safety and efficacy of cannabidiol in dogs and cats The market of cannabidiol (CBD) products for use in pets is…

CBD for veterinary use

Pharmacokinetcs/safety Desbold et al Single-dose pharmacokinetics and preliminary safety assessment with use
of …

Scholar Studies and Research: CBD

Mostly high quality evidence conducted in the past 2 years. Product names disclosed in most cases. Most convincing evidence…

Cannabinoids in veterinary medicine

The purpose of this analysis was to better understand the safety, efficacy and pharmacokinetics of cannabinoids…

Contraindications

The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects

TOM LYNCH, PharmD, and AMY PRICE, MD

Safety

Safety study of cannabidiol products in healthy dogs

2024 William Bookout, Margitta Dziwenka, Kaiti Valm, Jennifer Kovacs-Nolan

Preliminary Investigation of the Safety of Escalating Cannabinoid Doses in Healthy Dogs

Dana Vaughn*, Justyna Kulpa and Lina Paulionis

Toxicology

Marijuana exposure in animals

Caroline W. Donaldson, DVM

Marijuana Poisoning

Kevin T. Fitzgerald, Alvin C. Bronstein, Kristin L. Newquist

Medical conditions

Autoimmune conditions

Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes.

E. B. Russo, 2016

Anti-inflammatory

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease

Francesca Borrelli a,1,*, Ines Fasolino a, Barbara Romano a, Raffaele Capasso a,1, Francesco Maiello b, Diana Coppola b, Pierangelo Orlando c,1, Giovanni Battista b, Ester Pagano a, Vincenzo Di Marzo d,1, Angelo A. Izzo a,1,*

Analgesic and anti-inflammatory activity of constituents of cannabis sativa l

E.A. Formukong, A.T. Evans, and F.J. Evans

Anxiety

Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models

2024 Guangzhao Shu, Yang Heet al.

Is cannabidiol (CBD) effective to ease separation anxiety?

2024 Nobuo Masataka

Antianxiety effect of cannabidiol in the elevated plus-maze

F.S. Guimarães 1, T.M. Chiaretti 1, F.G. Graeff 3, and A.W. Zuardi 2

Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation

Cindy H.J. Yu, H.P. Vasantha Rupasinghe, 2021

A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel

A. Hunt, H. Flint, D. Logan and T. King 2023

Cancer

Cannabinoids: Potential anticancer agents

Guzman, M.

Cannabinoids as therapeutic agents in cancer: current status and future implications

Bandana Chakravarti1,*, Janani Ravi2,* and Ramesh K. Ganju2

Feline Chronic Gingivostomatitis (FCGS)

Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis

2023 Joana Chambel Coelho, Noélia Duarte, et al

Nausea

Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus

E M Rock, R L Kopstick, C L Limebeer and L A Parker

Cannabinoid Regulation of Acute and Anticipatory Nausea

Erin M. Rock,1 Martin A. Sticht,2 Cheryl L. Limebeer1 and Linda A. Parker1,*

Neuropharmacology

THC and gabapentin interactions in a mouse neuropathic pain model

Nicholas Atwal, Sherelle L. Casey, Vanessa A. Mitchell, Christopher W. Vaughan∗

Role of Cannabinoids in the Treatment of Pain and (Painful) Spasticity

Matthias Karst, Sonja Wippermann and Jo ̈rg Ahrens

Cannabidiol in vivo blunts b-amyloid induced neuroinflammation by suppressing IL-1b and iNOS expression

G Esposito1, C Scuderi1, C Savani1, L Steardo Jr2 , D De Filippis3 , P Cottone1 , T Iuvone3, V Cuomo1 and L Steardo1

Osteoarthritis

Thai veterinarians' perceptions of cannabidiol products for dogs with osteoarthritis: a qualitative interview study

2023 Osot Nerapusee, Kumpanart Soontornvipart et al

Efficacy and safety of cannabidiol for the treatment of canine osteoarthritis: a systematic review and meta-analysis of animal intervention studies

2023 C. Patikorn, O. Nerapusee, K. Soontornvipartet al.

Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis

2023 Y. Shilo-Benjamini, E. Lavy, N. Yair, et al.

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

Lauri-Jo Gamble1, Jordyn M. Boesch1, Christopher W. Frye1, Wayne S. Schwark2, Sabine Mann3, Lisa Wolfe4, Holly Brown5, Erin S. Berthelsen1 and Joseph J. Wakshlag1*

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

Chris D. Verricoa,b, Shonda Wessonc, Vanaja Kondurid, Colby J. Hofferekd, Jonathan Vazquez-Perezd, Emek Blaire, Kenneth Dunner Jrf, Pedram Salimpourg, William K. Deckerd,h,i, Matthew M. Halpertd,*

Pain

Efficacy and safety of cannabidiol for the treatment of canine osteoarthritis: a systematic review and meta-analysis of animal intervention studies

2023 C. Patikorn, O. Nerapusee, K. Soontornvipartet al.

Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis

2023 Y. Shilo-Benjamini, E. Lavy, N. Yair, et al.

The role of cannabinoids in pain modulation in companion animals.

Cortes, Rojas, et al. 2023

Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation

Cindy H.J. Yu, H.P. Vasantha Rupasinghe, 2021

Skin Conditions

Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders

Sudhir M Baswan 1, Allison E Klosner 2, Kelly Glynn 1, Arun Rajgopal1 Kausar Malik 1, Sunghan Yim 1, Nathan Stern

Seizures/ Epilepsy

The efficacy and safety of cannabidiol as adjunct treatment for drug‐resistant idiopathic epilepsy in 51 dogs: A double‐blinded crossover study

2023 Aaron J. Rozental, Brooke G. Weisbeck,et al.

Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy

2019 Stephanie McGrath, Lisa R Bartner, Sangeeta Rao, Rebecca A Packer, Daniel L Gustafson

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?

Emilio Perucca 1,2

Cannabidiol in canine epilepsy

2022. Heidrun Potschka, Sofie F M Bhatti, Andrea Tipold, Stephanie McGrath

Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs

2022. Gabriel A. Garcia Stephanie Kube, Sheila Carrera-Justiz1 David Tittle. Joseph J. Wakshlag

Animals

Birds

Twice-daily oral administration of a cannabidiol and cannabidiolic acid-rich hemp extract was well tolerated in orange-winged Amazon parrots (Amazona amazonica) and has a favorable pharmacokinetic profile.

Carpenter, Tully Jr, et al. 2022

Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model

Alalawi, Dodu et al. 2022

Pharmacokinetics of Cannabidiol in the Hispaniolan Amazon Parrot.

Carpenter, Tully Jr, et al. 2022

Cannabinoid receptor 2 evolutionary gene loss makes parrots more susceptible to neuroinflammation.

Divin, Gomez Samblas, et al. 2022

Cats

Disposition of a single oral dose of a cannabidiol medication in healthy cats

2023 Tom Jukier, Crisanta Cruz-Espindola,et al

Healthy cats tolerate long-term daily feeding of Cannabidiol

2024 Jennifer C Coltherd, Robyn Bednall, et al.

Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis

2023 Joana Chambel Coelho, Noélia Duarte, et al

Is cannabidiol (CBD) effective to ease separation anxiety? (Cat study)

2024 Nobuo Masataka

A case report of CBD and THC as analgesic therapy in a cat with chronic osteoarthritic pain

2023 E Gutierre,1 N Crosignani, et al.

Safety and tolerability of escalating cannabinoid doses in healthy cats

Kulpa, J.E. et al 2021

Cognitive Dysfunction in Cats: Clinical Assessment and Management

Danièlle A. Gunn-Moore, PhD

Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases

I. Alvarenga, K. Panickar, H. Hess, and S. McGrath 2023

Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats

A. J. Rozental, D, L. Gustafson, et al. 2022

Dogs

Safety study of cannabidiol products in healthy dogs

2024 William Bookout, Margitta Dziwenka, Kaiti Valm, Jennifer Kovacs-Nolan

The efficacy and safety of cannabidiol as adjunct treatment for drug‐resistant idiopathic epilepsy in 51 dogs: A double‐blinded crossover study

2023 Aaron J. Rozental, Brooke G. Weisbeck,et al.

Efficacy and safety of cannabidiol for the treatment of canine osteoarthritis: a systematic review and meta-analysis of animal intervention studies

2023 C. Patikorn, O. Nerapusee, K. Soontornvipartet al.

Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis

2023 Y. Shilo-Benjamini, E. Lavy, N. Yair, et al.

Scientific Validation of Cannabidiol for Management of Dog and Cat Diseases

I. C. Alvarenga, K. S. Panickar, et al. 2023

Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs

S. Bradley, S. Young, et al. 2022

The Impact of Feeding Cannabidiol (CBD) Containing Treats on Canine Response to a Noise-Induced Fear Response Test

E. M. Morris, S. E. Kitts-Morgan, et al. 2020

Elephants

Preliminary Evaluation of Cannabidiol Use in an Asian Elephant: Brief Report

Ortiz, Castillo, Hernandez, Flores

Horses

Cannabidiol and the possibilities of its use in veterinary medicine of dogs and horses: A brief review

L. Landa, V. Trojan, R. Demlova, J. Jurica, R. Hrib, 2023

Mice

Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models

2024 Guangzhao Shu, Yang Heet al.

CB1 receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by Bothrops jararaca lancehead pit vipers.

Rodrigues, Coimbra 2022

Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm.

Marino, Francisco, et al. 2011

Rabbits

Feeding decreases the oral bioavailability of cannabidiol and cannabidiolic acid in hemp oil in New Zealand White rabbits.

Rooney, Carpenter, et al.

Rats

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.

Philpott, O’Brien, McDougall 2017

Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension.

Krzyżewska et al. 2022

Topics

List of topics:

Literature reviews

Pharmacokinetics, safety and efficacy

Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge (2023) ​

Pharmacokinetics, safety and efficacy

CBD for veterinary use

CBD for veterinary use

Scholar Studies and Research: CBD

Scholar Studies and Research: CBD

Cannabinoids in veterinary medicine

Cannabinoids in veterinary medicine

Contraindications

Safety

Toxicology

Medical conditions

Autoimmune conditions

Anti-inflammatory

Anxiety

Cancer

Feline Chronic Gingivostomatitis (FCGS)

Nausea

Neuropharmacology

Osteoarthritis

Pain

Skin Conditions

Seizures/ Epilepsy

Animals

Birds

Cats

Dogs

Elephants

Horses

Mice

Rabbits

Rats

Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge (2023)